Genotype‐Dependent Modulation of LC‐Mediated Arousal by RAVANS: Evidence from Pupil Responses in an Oddball Task
RAVANS modulates LC-mediated attention in a genotype- and LC Integrity-dependent manner, with significant effects in ApoE E4 carriers. These findings highlight the potential for personalized neuromodulation strategies to optimize arousal in AD risk management, particularly for E4 carriers with preserved LC Integrity. Future studies will explore additional cognitive and neurobiological factors, such as tau pathology and LC activity, to refine RAVANS applications for early AD intervention.
Authors
- Heidi I.L. Jacobs (ORCID: https://orcid.org/0000-0001-7620-3822)
- L. Heinrich (ORCID: https://orcid.org/0000-0002-4048-7584)
- Roberta Sclocco (ORCID: https://orcid.org/0000-0001-8837-5218)
- Vitaly Napadow (ORCID: https://orcid.org/0000-0003-1941-1750)
- Joost M. Riphagen (ORCID: https://orcid.org/0000-0002-0888-386X)
- Maxime Van Egroo (ORCID: https://orcid.org/0000-0002-3142-2623)
- Nina Engels
- Gabriel Wainstein
- Jill Grube
- Ronald Garcia
- Marion Baillet
Institutions
- Harvard University (US)
- Spaulding Rehabilitation Hospital (US)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108943
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00