Unveiling the Temporal Dynamics of White Matter Hyperintensities Related to Alzheimer’s Disease in Down Syndrome
WMH decreased more frequently over time in DS compared to the general population, particularly in individuals with symptomatic AD and high baseline WMH volume. This unexpected finding, which cannot be attributed to atrophy, offers novel insights into WMH aetiology in DS and has significant implications for targeted interventions using WMH as an outcome.
Authors
- Olivia Belbin (ORCID: https://orcid.org/0000-0002-6109-6371)
- Bessy Benejam (ORCID: https://orcid.org/0000-0002-6789-8615)
- Lucía Maure‐Blesa
- Laura Videla (ORCID: https://orcid.org/0000-0002-9748-8465)
- Isabel Barroeta (ORCID: https://orcid.org/0000-0003-2764-7923)
- María Carmona‐Iragui (ORCID: https://orcid.org/0000-0001-6914-2339)
- José Enrique Arriola‐Infante (ORCID: https://orcid.org/0000-0002-3298-4601)
- Sandra M. Giménez
- Alexandre Bejanin (ORCID: https://orcid.org/0000-0002-9958-0951)
- Javier Arranz (ORCID: https://orcid.org/0000-0003-0891-1215)
- Juan M. Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- Daniel Alcolea
- Alberto Lleó
- María Franquesa‐Mullerat (ORCID: https://orcid.org/0009-0006-1484-7132)
- Aida Sanjuan Hernandez
- Laura Del Hoyo
- Sara E Zsadanyi
- Zili Zhao
- Susana Fernandez
- Jose Allende Parra
- Mateus Rozalem Aranha
- Íñigo Rodríguez‐Baz
- Alejandra O. Morcillo‐Nieto
- Lídia Vaqué‐Alcázar
Institutions
- Universitat Autònoma de Barcelona (ES)
- Hospital de Sant Pau (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_110296
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00