Associations of Lancet Commission risk factors for Alzheimer's disease with blood‐based biomarkers and mild cognitive impairment from midlife to early old age
Correlated Lancet Commission risk factors when considered together, accounted for relatively little of the variance in plasma NfL, GFAP, or MCI in men across 6 years from late midlife to early old age. The modifiable risk factors contributed more strongly than APOE and/or age. Top predictors for biomarkers and MCI were similar (glucose, BMI, PM2.5, education) illustrating the importance of modifiable health and environmental factors. These results highlight the complex health and lifestyle etiologies of AD-related plasma biomarkers and may signal areas of opportunity for early intervention.
Authors
- Erik Buchholz
- Tyler Bell (ORCID: https://orcid.org/0000-0001-5702-5995)
- Christine Fennema‐Notestine (ORCID: https://orcid.org/0000-0002-6527-6361)
- Jeremy A. Elman (ORCID: https://orcid.org/0000-0002-5840-1769)
- Robert A. Rissman (ORCID: https://orcid.org/0000-0001-9245-8278)
- ARTHUR WINGFIELD
- William S. Kremen (ORCID: https://orcid.org/0000-0002-8629-5609)
- McKenna E. Williams (ORCID: https://orcid.org/0000-0002-4106-5025)
- Michael C. Neale (ORCID: https://orcid.org/0000-0003-4887-659X)
- Amy J. Jak (ORCID: https://orcid.org/0000-0001-8588-1430)
- Tina Vo
- Nathan A. Gillespie (ORCID: https://orcid.org/0000-0001-8655-2823)
- Michael J. Lyons (ORCID: https://orcid.org/0000-0001-6516-9219)
- Carol E. Franz (ORCID: https://orcid.org/0000-0002-8987-1755)
- Paula Iso‐Markku (ORCID: https://orcid.org/0000-0001-6683-919X)
- Rongxiang Tang (ORCID: https://orcid.org/0000-0003-0406-9024)
- Alexander Ivan B. Posis (ORCID: https://orcid.org/0000-0002-7317-0444)
- Chandra A Reynolds
- Daniel E. Gustavson
- Matthew S. Panizzon
- the Vietnam Era Twin Study of Aging (VETSA)
- Ryan O'Leary
- Jack F.V. Hunt
Institutions
- University of Arkansas at Little Rock (US)
- University of Southern California (US)
- Virginia Commonwealth University (US)
- University of Colorado Boulder (US)
- Helsinki University Hospital (FI)
- University of California San Diego (US)
- Human Longevity (United States) (US)
- Brandeis University (US)
- University of California, Davis (US)
- Southern States University (US)
- Texas A&M University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_105091
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00