Episodic memory network connectivity with aging and Alzheimer’s disease pathology in cognitively unimpaired older adults
Our results do not support the initial hypothesis, which predicted hyperconnectivity in distinct brain regions with high pathology. This could be due to relatively low overall pathology burden, consistent with an early preclinical stage of potential disease progression. This interpretation is further supported by the absence of significant associations between pathology or rsFC strength and memory performance. We identified lower rsFC strength in two distinct connections with higher blood-based pathology. These alterations were not observed in the A-T- subcohort, suggesting it to be an early marker differentiating pathological from healthy aging.
Authors
- Emrah Düzel (ORCID: https://orcid.org/0000-0002-0139-5388)
- Anne Hochkeppler
- Michael Rullmann (ORCID: https://orcid.org/0000-0002-2683-9432)
- Andrew Stephens (ORCID: https://orcid.org/0000-0001-5052-6586)
- Osama Sabri
- Berta Garcia‐Garcia (ORCID: https://orcid.org/0000-0002-8585-6507)
- Svenja Schwarck (ORCID: https://orcid.org/0000-0003-2024-9236)
- Larissa Fischer (ORCID: https://orcid.org/0009-0001-9936-2954)
- Enise I. Incesoy (ORCID: https://orcid.org/0000-0003-2014-4098)
- Hermann Esselmann (ORCID: https://orcid.org/0000-0001-5484-9710)
- Bárbara Morgado (ORCID: https://orcid.org/0000-0001-8174-9301)
- Michael C. Kreißl (ORCID: https://orcid.org/0000-0001-5905-6015)
- Andreas Schildan (ORCID: https://orcid.org/0000-0002-9418-3826)
- Beate Schumann‐Werner (ORCID: https://orcid.org/0000-0002-3530-5766)
- Eóin N. Molloy (ORCID: https://orcid.org/0000-0002-7804-2214)
- Marianne Patt (ORCID: https://orcid.org/0000-0001-6492-4104)
- Jens Wiltfang
- Niklas Behrenbruch
- Anna‐Therese Büchel
- Gusalija Behnisch
- Anne Maass
- Björn H. Schott
- Henryk Barthel
- Julia Gatzen
- Constanze I. Seidenbecher
Institutions
- University of California, Irvine (US)
- German Center for Neurodegenerative Diseases (DE)
- Universitätsmedizin Göttingen (DE)
- University of Göttingen (DE)
- Leipzig University (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- Leibniz Institute for Neurobiology (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108678
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00