Walking to Protect Against Cognitive Decline: The Role of APOE Genotype, Sex, and Race
APOE ε4 carriers displayed an elevated risk of cognitive decline; greater physical activity was significantly protective in this at-risk group. Greater walking was associated with better executive function/processing speed in white ε4 carriers, and better global cognition in black ε4 carrier. These findings underscore the importance of tailoring public messaging about physical activity strategies to at-risk vulnerable populations and highlight the intersection of genetic, sex, demographic, and lifestyle factors in cognitive aging research.
Authors
- Joel S. Burma (ORCID: https://orcid.org/0000-0001-9756-5793)
- John R. Best (ORCID: https://orcid.org/0000-0001-5775-7053)
- Cindy K. Barha (ORCID: https://orcid.org/0000-0003-3149-5539)
- Caterina Rosano (ORCID: https://orcid.org/0000-0002-0909-1506)
- Teresa Liu‐Ambrose
Institutions
- University of British Columbia (CA)
- University of Calgary (CA)
- University of Pittsburgh (US)
- Simon Fraser University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_103779
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00