Single‐cell spatial transcriptomics reveals shared transcriptional responses to amyloid proximity in Alzheimer's disease and type 2 diabetes
Here we spatially investigate the impact of amyloid deposits on the cellular and transcriptomic microenvironment in the brain and pancreas. Our analysis revealed a common set of amyloid proximity related genes, providing insight into potentially shared pathological pathways underlying AD and T2D.
Authors
- Kristie Aamodt (ORCID: https://orcid.org/0000-0003-0065-0786)
- Adel Eskaros (ORCID: https://orcid.org/0000-0001-9028-338X)
- Madeline E. Colley (ORCID: https://orcid.org/0000-0002-9515-3493)
- Thai Pham (ORCID: https://orcid.org/0000-0002-6124-7678)
- Alvin C. Powers (ORCID: https://orcid.org/0000-0003-1941-5786)
- Claire F. Scott (ORCID: https://orcid.org/0000-0002-8467-3370)
- Jeffrey M. Spraggins (ORCID: https://orcid.org/0000-0001-9198-5498)
- Matthew Schrag (ORCID: https://orcid.org/0000-0001-7048-0503)
- Cody R. Marshall (ORCID: https://orcid.org/0009-0005-9639-0537)
- Raf Van de Plas
- Melissa A. Farrow
- Morad C. Malek
- Angela R. S. Kruse
- Lukasz G. Migas
- Joana P. Gonçalves
- Roy Lardenoije
Institutions
- Vanderbilt University (US)
- VA Tennessee Valley Healthcare System (US)
- Vanderbilt Health (US)
- Vanderbilt University Medical Center (US)
- Delft University of Technology (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_098987
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00