Genetic and Causal Insights Into White Matter Hyperintensities Across the Brain‐Body Axis
Our findings highlight systemic multi-tissue contributions (CNS, liver, cardiovascular system, and kidneys) to WMHs, driven by vascular endothelial dysfunction and shared AD genetics, with SNPs across the body also affecting brain imaging derived phenotypes.
Authors
- Kimia Shafighi (ORCID: https://orcid.org/0000-0003-0285-5865)
- Nils D. Forkert (ORCID: https://orcid.org/0000-0003-2556-3224)
- Manpreet Singh (ORCID: https://orcid.org/0000-0003-0816-8687)
- Gabrielle Dagasso (ORCID: https://orcid.org/0000-0002-5037-4292)
- AmanPreet Badhwar (ORCID: https://orcid.org/0000-0003-3414-3395)
- Flavie E. Detcheverry (ORCID: https://orcid.org/0000-0002-9909-9754)
- Ikrame Housni
- Fanta Dabo
- Danilo Bzdok
- Sridar Narayanan
- Sarah A Gagliano Taliun
Institutions
- Montreal Neurological Institute and Hospital (CA)
- University of Calgary (CA)
- Montreal Heart Institute (CA)
- McGill University Health Centre (CA)
- Institute for Neurodegenerative Disorders (US)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Mila - Quebec Artificial Intelligence Institute (CA)
- Hotchkiss Brain Institute (CA)
- McGill University (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_110035
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00