Association of Neighborhood‐Level Disadvantage with Antemortem MRI Brain Volumes in a Multi‐site Brain Bank Donor Cohort
Dementia was associated with greater global atrophy and lower brain volumes among disadvantaged individuals. These findings suggest that socioeconomic disadvantage may amplify dementia-related brain changes. The small number of participants with both dementia and high disadvantage (n = 14) is a limitation, underscoring the need for greater socioeconomic representation in future studies.
Authors
- Julia Kofler (ORCID: https://orcid.org/0000-0003-4298-7328)
- Ruvini Navaratna (ORCID: https://orcid.org/0000-0003-2924-8520)
- Judith Neugroschl (ORCID: https://orcid.org/0000-0001-8395-8406)
- Tobey J. Betthauser (ORCID: https://orcid.org/0000-0001-8856-1352)
- Jason F. Moody (ORCID: https://orcid.org/0000-0002-5854-9659)
- Carmen I. Carrión (ORCID: https://orcid.org/0000-0002-7981-9793)
- Jill K. Morris (ORCID: https://orcid.org/0000-0001-5911-4190)
- David L. Sultzer
- Paola Espinoza (ORCID: https://orcid.org/0000-0001-9537-538X)
- Henry L. Paulson (ORCID: https://orcid.org/0000-0002-0382-7535)
- Angel Hammond
- Michael L. Alosco (ORCID: https://orcid.org/0000-0002-8113-8428)
- EM Reiman
- Anthony Fabio (ORCID: https://orcid.org/0000-0002-6808-4939)
- Karyn Marsh (ORCID: https://orcid.org/0009-0003-9057-1551)
- Kelly M. Bakulski (ORCID: https://orcid.org/0000-0002-9605-6337)
- Rebecca J. Lepping (ORCID: https://orcid.org/0000-0001-9269-051X)
- Oanh L. Meyer (ORCID: https://orcid.org/0000-0002-1093-0477)
- Jessica B. Langbaum (ORCID: https://orcid.org/0000-0003-3848-1324)
- Adam P. Mecca (ORCID: https://orcid.org/0000-0003-1982-5443)
- Joshua Chodosh (ORCID: https://orcid.org/0000-0001-7784-4306)
- Carolyn W. Zhu (ORCID: https://orcid.org/0000-0002-2318-715X)
- Amanda DeWitt (ORCID: https://orcid.org/0000-0003-3190-3475)
- Margaret O’Connor
- Andrew Joel Saykin
- A. Atri
- Sarah Farias
- William R. Buckingham
- Jennifer H Lingler
- Mary Sano
- Amy J.H. Kind
- James B. Brewer
- Jonathan D Mahnken
- Barbara B. Bendlin
- Thomas Wisniewski
- Rachel A. Whitmer
- Thomas G. Beach
- C. Elizabeth Shaaban
- W. Ryan Powell
- Victor W Henderson
Institutions
- Boston University (US)
- University of Wisconsin–Madison (US)
- University of Kansas (US)
- University of Pittsburgh (US)
- Palo Alto University (US)
- University of California, Irvine (US)
- University of Michigan (US)
- Banner Health (US)
- Yale University (US)
- University of California San Diego (US)
- Mount Sinai Hospital (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Geriatric Research Education and Clinical Center (US)
- University of Kansas Medical Center (US)
- Banner Sun Health Research Institute (US)
- Imaging Center (US)
- Banner Alzheimer’s Institute
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- New York University (US)
- University of California, Davis (US)
- Stanford University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108929
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00