Tau burden across Braak stages is associated with regionally specific amyloid accumulation: insights from the BIOCARD cohort

Amyloid-tau interactions show regional specificity with medial OFC amyloid burden showing a strong association with early tau pathology accumulation while amyloid in the precuneus is selectively associated with tau in later stages. These findings suggest that localized measures of amyloid burden may enhance early detection and show utility in understanding amyloid-tau dynamics.