Baseline and long‐term longitudinal atrophy patterns of cognitively unimpaired individuals with elevated plasma ptau‐217

This large-scale longitudinal imaging study demonstrates that elevated plasma p-tau217 levels can identify cognitively unimpaired individuals who are on a neurodegenerative trajectory towards AD. This emphasizes the diagnostic value of plasma p-tau217 for early intervention and monitoring of AD progression.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70862_109886
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Baseline and long‐term longitudinal atrophy patterns of cognitively unimpaired individuals with elevated plasma ptau‐217

Michel J. Grothe, Cristina Cadenas‐Sánchez, Pascual Sánchez‐Juan, Linda Zhang et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Baseline and long‐term longitudinal atrophy patterns of cognitively unimpaired individuals with elevated plasma ptau‐217

Michel J. Grothe, Cristina Cadenas‐Sánchez, Pascual Sánchez‐Juan, Linda Zhang, Jesús Silva‐Rodríguez, Elizabeth Lucia Valeriano‐Lorenzo, Sonia Wagner, Teodoro del Ser, Francisco J. López‐González
article en

Abstract

This large-scale longitudinal imaging study demonstrates that elevated plasma p-tau217 levels can identify cognitively unimpaired individuals who are on a neurodegenerative trajectory towards AD. This emphasizes the diagnostic value of plasma p-tau217 for early intervention and monitoring of AD progression.

Alzheimer s & DementiaVol. 21(S8)
Fundacion Centro De Investigacion De Enfermedades Neurologicas (ES)
Openalex Percentile: Top 35%
Dementia and Cognitive Impairment Research
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