ApoE4 accelerates <i>p</i> ‐tau driven tau aggregation and spread in Alzheimer's Disease in a allele‐dose dependent manner
ApoE4 exerts an allele dose-dependent effect on ptau induced tau aggregation, driving accelerated tau spreading at lower Aβ levels. This suggests that attenuating soluble ptau increases in ApoE4 carriers may mitigate downstream tau fibrilisation and delay dementia onset, highlighting the potential of personalised therapeutic approaches.
Authors
- Amir Dehsarvi (ORCID: https://orcid.org/0000-0001-7116-9741)
- Anna Steward (ORCID: https://orcid.org/0000-0002-8438-3760)
- Johannes Gnörich (ORCID: https://orcid.org/0000-0003-1554-7765)
- Fabian Hirsch (ORCID: https://orcid.org/0000-0002-5370-4031)
- M. Brendel
- Nicolai Franzmeier (ORCID: https://orcid.org/0000-0001-9736-2283)
- Davina Biel (ORCID: https://orcid.org/0000-0002-2597-1992)
- Sebastian N. Roemer‐Cassiano
- Zeyu Zhu
- Anna Dewenter
- Lukas Frontzkowski
- Madleen Klonowksi
Institutions
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- Munich Cluster for Systems Neurology (DE)
- Max Planck Institute for Human Cognitive and Brain Sciences (DE)
- Ludwig-Maximilians-Universität München (DE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_109847
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00