Focal hotspot and diffuse immune subtypes of tumor-infiltrating lymphocytes: AI-powered spatial clustering classification and its clinical relevance to HER2 expression in triple-negative breast cancer
This study distinguished focal hotspot and diffuse immune subtypes of TILs with distinct clinical implications in TNBC. The diffuse immune subtype correlated with enhanced NAC response and favorable prognosis, particularly in HER2-low TNBC. These findings highlighted the spatial immune architecture as a promising biomarker to refine treatment stratification and deepen our understanding of immune heterogeneity in HER2-low TNBC.
Authors
- Bin Luo (ORCID: https://orcid.org/0000-0003-1061-1019)
- Honglin Yan (ORCID: https://orcid.org/0000-0002-2597-6902)
- H Zhang
- Shuying Ai
- Jingping Yuan
- Zhongtao Chen
- Tian Jin
- Chen Liu
- Ting Xie
- Shuaijun Chen
Institutions
- Wuhan University (CN)
- Klinikum Hanau (DE)
- Renmin Hospital of Wuhan University (CN)
- Central Hospital of Wuhan (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1186/s12967-025-07608-7
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Wuhan University
- Renmin Hospital of Wuhan University