Visualization of accumulated, physiologically generated Dutch‐type Aβ oligomers associated with impaired learning and abnormal presynaptic physiology but no detectable neuroinflammation
Dutch oAβ accumulation associates with aging-related defects in learning behavior, presynaptic function & mitochondrial structure & function. Brain PET imaging with Lys(64Cu /NOTA)]-CP may enable development of an assay for monitoring oAβ levels & distribution for diagnosing living human subjects & patients.
Authors
- Francesca Garretti (ORCID: https://orcid.org/0000-0002-6609-8034)
- Kuldeep Tripathi (ORCID: https://orcid.org/0000-0003-4850-0218)
- Brigitte Guérin (ORCID: https://orcid.org/0000-0002-0319-4512)
- DARA L. DICKSTEIN
- Lars Lannfelt (ORCID: https://orcid.org/0000-0001-9839-659X)
- David K. Lerner (ORCID: https://orcid.org/0000-0002-0431-2920)
- WILLIAM D. LUBELL
- H Z Zhang
- Elentina K. Argyrousi (ORCID: https://orcid.org/0000-0003-3716-807X)
- Ottavio Arancio (ORCID: https://orcid.org/0000-0001-6335-164X)
- B. T. Teunissen
- Shai Rahimipour (ORCID: https://orcid.org/0000-0002-3210-1645)
- Michelle E. Ehrlich (ORCID: https://orcid.org/0000-0001-9397-686X)
- Ronan Talty (ORCID: https://orcid.org/0000-0002-8742-3799)
- Merina Varghese (ORCID: https://orcid.org/0000-0002-1517-3903)
- Charles Glabe (ORCID: https://orcid.org/0000-0002-0599-0184)
- Erin Bresnahan
- Emilie L. Castranio (ORCID: https://orcid.org/0000-0001-6817-7388)
- Jonathan Van de Loo (ORCID: https://orcid.org/0009-0003-5275-9246)
- Minghui Wang (ORCID: https://orcid.org/0000-0003-0022-5034)
- B Zhang
- Linda Söderberg
- Sam E Gandy
- Efrat Levy
Institutions
- Nathan Kline Institute for Psychiatric Research (US)
- Alzheimer's Drug Discovery Foundation (US)
- Université de Sherbrooke (CA)
- Bar-Ilan University (IL)
- Uniformed Services University of the Health Sciences (US)
- University of California, Irvine (US)
- Center for Information Technology (US)
- Yale University (US)
- James J. Peters VA Medical Center (US)
- BioArctic Neuroscience (Sweden) (SE)
- New York University (US)
- Université de Montréal (CA)
- Columbia University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_110303
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00