Blood pressure lowering to prevent dementia, the role or frailty, when not to treat?

Antihypertensive treatment is likely to reduce incident dementia in those aged∼60-80 across varying levels of frailty. However, since clinical trial populations are biassed towards less frail participants, there are limitations to the generalizability of these data to more severe frailty in the general population. Further analyses will allow the investigation of the frailty/antihypertensive/dementia relationship in more detail. These data have implications for treatment guidelines for cardiovascular prevention alongside approaches to the management of people at high-risk of dementia. 1. Eur Heart J 2022;43(48):4980-90 2. JAMA Intern Med;2022;182(2):142-52 3. Lancet Neurol;2018;18(2):17784 4. Nat Aging;2021;1:651-65 5. Lancet Health Longev;2023;2(2)e96-e104.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70860_098290
Primary Topic
Frailty in Older Adults
Type
article
Field-Weighted Citation Impact
0.00
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article

Blood pressure lowering to prevent dementia, the role or frailty, when not to treat?

Craig S. Anderson, Ruth Peters, Nigel Beckett, Jan A. Staessen et al.
Alzheimer s & Dementia
Frailty in Older Adults
article

Blood pressure lowering to prevent dementia, the role or frailty, when not to treat?

Craig S. Anderson, Ruth Peters, Nigel Beckett, Jan A. Staessen, Christophe Tzourio, K. Rockwood, Linan Chen, John Chalmers, Mark Woodward, C J Bulpitt, JD Williamson, Katie Harris, Xiaoying Chen, Françoise Forette, Wang Ruirui
article en

Abstract

Antihypertensive treatment is likely to reduce incident dementia in those aged∼60-80 across varying levels of frailty. However, since clinical trial populations are biassed towards less frail participants, there are limitations to the generalizability of these data to more severe frailty in the general population. Further analyses will allow the investigation of the frailty/antihypertensive/dementia relationship in more detail. These data have implications for treatment guidelines for cardiovascular prevention alongside approaches to the management of people at high-risk of dementia. 1. Eur Heart J 2022;43(48):4980-90 2. JAMA Intern Med;2022;182(2):142-52 3. Lancet Neurol;2018;18(2):17784 4. Nat Aging;2021;1:651-65 5. Lancet Health Longev;2023;2(2)e96-e104.

Alzheimer s & DementiaVol. 21(S6)
Guy's Hospital (GB), Dalhousie University (CA), Université de Bordeaux (FR), Inserm (FR), The George Institute for Global Health (GB), UNSW Sydney (AU), International Longevity Centre (GB), Bordeaux Population Health (FR), The George Institute for Global Health (AU), Wake Forest University (US), Imperial College London (GB)
Openalex Percentile: Top 35%
Frailty in Older Adults
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Blood pressure lowering to prevent dementia, the role or frailty, when not to treat? — Craig S. Anderson, Ruth Peters, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS