Patient‐Derived iPSC Neuronal Models Reveal Alzheimer’s Disease‐Associated Pathology and Provide a Platform for Drug Discovery

Our iPSC-based AD Panel provides a robust, human-relevant model for studying sporadic AD pathophysiology. The ability to recapitulate key AD hallmarks in patient-derived neurons supports their use in target validation, biomarker identification, and personalized drug screening. This scalable model facilitates therapeutic discovery and precision medicine approaches in AD research.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70861_108650
Primary Topic
Pluripotent Stem Cells Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Patient‐Derived iPSC Neuronal Models Reveal Alzheimer’s Disease‐Associated Pathology and Provide a Platform for Drug Discovery

Elixirgen Scientific R&D, Nadezhda Eckert
Alzheimer s & Dementia
Pluripotent Stem Cells Research
article

Patient‐Derived iPSC Neuronal Models Reveal Alzheimer’s Disease‐Associated Pathology and Provide a Platform for Drug Discovery

Elixirgen Scientific R&D, Nadezhda Eckert
article en

Abstract

Our iPSC-based AD Panel provides a robust, human-relevant model for studying sporadic AD pathophysiology. The ability to recapitulate key AD hallmarks in patient-derived neurons supports their use in target validation, biomarker identification, and personalized drug screening. This scalable model facilitates therapeutic discovery and precision medicine approaches in AD research.

Alzheimer s & DementiaVol. 21(S7)
Elixir Medical (United States) (US)
Openalex Percentile: Top 36%
Pluripotent Stem Cells Research
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