<i>APOE</i> *4 and Cell‐Type‐specific Risk‐Modifying Genes in Alzheimer’s Disease
We identified multiple AD risk-modifying genes dependent on both cellular context and APOE*4 status. These insights may inform therapeutic strategies aimed at APOE*4 and guide experimental interrogation of APOE's pathogenic mechanisms across brain cell types.
Authors
- Vilas Menon (ORCID: https://orcid.org/0000-0002-4096-8601)
- Danielle Marie Reid (ORCID: https://orcid.org/0000-0002-3316-9115)
- Michael D. Greicius (ORCID: https://orcid.org/0000-0002-5462-9037)
- Michaël E. Belloy (ORCID: https://orcid.org/0000-0001-7748-9033)
- Chenyu Yang (ORCID: https://orcid.org/0000-0002-8027-7020)
- Masashi Fujita
- M. Ryan Corces
- Noah Cook
- Youjie Zeng
Institutions
- Gladstone Institutes (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- Columbia University Irving Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108597
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00