The sex divide: Modifiable risk factors and their relative associations with cognition

This study examined sex differences in multiple modifiable risk factors of AD and their relationship with cognition. We found that women experienced several more risk factors compared to men. Importantly, the risk factors had a larger, negative effect on cognition in women compared to men with the same risk factor. Together, these data suggest that women may be at greater risk of AD because they carry more risk factors, which have a greater impact on cognition. Results may inform future personalized prevention strategies for dementia risk reduction.