Association Between Day‐to‐Day Variation in Electroencephalographic (EEG) Sleep Features and Daytime Cognitive Function in Adults at Risk for Dementia

149 individuals had >=1 cognitive evaluation within 12 hours of an overnight EEG recording. Of these, 63 had 2 nights, and 37 had >=3 nights. Greater % REM sleep (+0.15 per 1SD greater REM sleep, SE 0.04 p = 0.0001) and relative REM theta power (+0.08 per 1SD greater relative REM theta power, SE 0.04, p = 0.02) the night before were associated with better cognitive performance the next morning, and there was a non-significant positive relationship (+0.06 per 1SD difference, SE 0.04, p = 0.11) between NREM delta power and cognitive performance the following morning. These effects were particularly strong in those with mild cognitive impairment (delta power interaction p = 0.055; theta power interaction p = 0.02) CONCLUSION: REM sleep theta power and NREM delta power may support day to day cognitive performance in older adults at high risk for dementia, particularly those with mild cognitive impairment, and may represent electrophysiologic therapeutic targets to support cognitive resilience.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70860_107491
Primary Topic
Sleep and related disorders
Type
article
Field-Weighted Citation Impact
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article

Association Between Day‐to‐Day Variation in Electroencephalographic (EEG) Sleep Features and Daytime Cognitive Function in Adults at Risk for Dementia

Andrew Lim, Haakon B. Nygaard, Penelope Slack, Paul Brewster et al.
Alzheimer s & Dementia
Sleep and related disorders
article

Association Between Day‐to‐Day Variation in Electroencephalographic (EEG) Sleep Features and Daytime Cognitive Function in Adults at Risk for Dementia

Andrew Lim, Haakon B. Nygaard, Penelope Slack, Paul Brewster, Nicole Anderson, Howard Feldman, Andrew Centen, Howard Chertkow, Dharmendra Gurve, Sylvie Belleville, Thien Thanh Dang‐Vu, Manuel Montero‐Odasso, for the CCNA‐CAN‐THUMBS‐UP Study Group
article en

Abstract

149 individuals had >=1 cognitive evaluation within 12 hours of an overnight EEG recording. Of these, 63 had 2 nights, and 37 had >=3 nights. Greater % REM sleep (+0.15 per 1SD greater REM sleep, SE 0.04 p = 0.0001) and relative REM theta power (+0.08 per 1SD greater relative REM theta power, SE 0.04, p = 0.02) the night before were associated with better cognitive performance the next morning, and there was a non-significant positive relationship (+0.06 per 1SD difference, SE 0.04, p = 0.11) between NREM delta power and cognitive performance the following morning. These effects were particularly strong in those with mild cognitive impairment (delta power interaction p = 0.055; theta power interaction p = 0.02) CONCLUSION: REM sleep theta power and NREM delta power may support day to day cognitive performance in older adults at high risk for dementia, particularly those with mild cognitive impairment, and may represent electrophysiologic therapeutic targets to support cognitive resilience.

Alzheimer s & DementiaVol. 21(S6)
Western University (CA), University of British Columbia Hospital (CA), Lawson Health Research Institute (CA), Sunnybrook Health Science Centre (CA), University of British Columbia (CA), University of Toronto (CA), University of Victoria (CA), Health Sciences Centre (CA), Baycrest Hospital (CA), University of California San Diego (US), Toronto Dementia Research Alliance (CA), Alzheimer’s Disease Neuroimaging Initiative (US), Occupational Cancer Research Centre (CA), Institut Universitaire de Gériatrie de Montréal (CA), Ontario Brain Institute (CA), Concordia University (CA), Université de Montréal (CA)
Openalex Percentile: Top 30%
Sleep and related disorders
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