Cross‐Sectional Links between Baseline Serum Cortisol Levels and Cognitive Performance, Sleep, and Brain MRI Findings in a Rural Aging South‐Indian Cohort

The findings suggest that lower serum cortisol levels, rather than higher levels as previously suggested, are associated with poorer cognitive performance in the attention domain and increased reliance on sleep medication. These results highlight the potential role of adrenal insufficiency, whether endogenous or exogenous, in cognitive function and sleep quality in aging populations. Further research is needed to explore this association by using diagnostic criteria to characterize adrenal insufficiency and investigating its impact on cognition and brain MRI volumes.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70860_106975
Primary Topic
Stress Responses and Cortisol
Type
article
Field-Weighted Citation Impact
0.00
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article

Cross‐Sectional Links between Baseline Serum Cortisol Levels and Cognitive Performance, Sleep, and Brain MRI Findings in a Rural Aging South‐Indian Cohort

Sumedha Mitra, Jonas S. Sundarakumar, CBR‐SANSCOG
Alzheimer s & Dementia
Stress Responses and Cortisol
article

Cross‐Sectional Links between Baseline Serum Cortisol Levels and Cognitive Performance, Sleep, and Brain MRI Findings in a Rural Aging South‐Indian Cohort

Sumedha Mitra, Jonas S. Sundarakumar, CBR‐SANSCOG
article en

Abstract

The findings suggest that lower serum cortisol levels, rather than higher levels as previously suggested, are associated with poorer cognitive performance in the attention domain and increased reliance on sleep medication. These results highlight the potential role of adrenal insufficiency, whether endogenous or exogenous, in cognitive function and sleep quality in aging populations. Further research is needed to explore this association by using diagnostic criteria to characterize adrenal insufficiency and investigating its impact on cognition and brain MRI volumes.

Alzheimer s & DementiaVol. 21(S6)
Indian Institute of Science Bangalore (IN)
No poverty
Openalex Percentile: Top 36%
Stress Responses and Cortisol
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