Parabacteroides goldsteinii mitigates parkinsonism in LRRK2 mutant mice by reducing neuroinflammation through Gut-Brain axis
P. goldsteinii colonization attenuates the progression of LRRK2-associated parkinsonism by restoring intestinal homeostasis and reducing neuroinflammation. These findings underscore the therapeutic potential of modulating the gut-immune-brain axis during the prodromal stage of PD.
Authors
- Chia-Chen Lu
- Huan-Yun Chen
- Lin Chin-Hsien
- Lin Jian-Da
- C. Liu (ORCID: https://orcid.org/0000-0001-8440-7171)
- Hsiao-Li Chuang (ORCID: https://orcid.org/0000-0002-3718-9076)
- Han-I Lin
- Hsun Li
- Hsin-Chih Lai
- Tzu-Lung Lin
- Chia-Lang Hsu
- Ya-Ting Chuang
- Ming-Shiang Wu
- Wei-Kai Wu
- En-Peng Ho
- Chia-Jung Lien
- Yi-Hsuan Chen
- Yun-Yi Lung
Institutions
- Fu Jen Catholic University (TW)
- National Taiwan University (TW)
- Chang Gung University (TW)
- National Taiwan University Hospital (TW)
- National Institutes of Applied Research (TW)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jare.2025.12.028
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61