Brain Structural Changes and Amyloid Burden Linked to Midlife Obesity and Insulin Resistance: Implications for Alzheimer's Disease Risk
Midlife obesity is associated with reduced volumes and higher amyloid burden in Alzheimer's disease-associated region of the brain. The lack of significant tau burden differences reflects the cohort's subclinical stage of the disease.
Authors
- Joseph E. Ippolito (ORCID: https://orcid.org/0000-0003-1913-5573)
- Bettina Mittendorfer (ORCID: https://orcid.org/0000-0003-0049-2677)
- Cyrus A. Raji (ORCID: https://orcid.org/0000-0002-9086-0105)
- Soheil Mohammadi (ORCID: https://orcid.org/0000-0003-0616-1780)
- LaKisha Lloyd
- Paul K. Commean
- Mahshid Naghashzadeh
- Farzaneh Rahmani
- Sara Hosseinzadeh Kasani
- Caitlyn Nguyen
- Tammie L.S. Benzinger
- Mahsa Dolatshahi
- John C. Morris
- Claude Sirlin
Institutions
- Washington University in St. Louis (US)
- University of California San Diego (US)
- Mallinckrodt (United States) (US)
- University of Missouri (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_098965
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00