Association of Centrally Acting Medications, Chronic Pain, and Orthopedic Surgical History with Cognitive Impairment and Neurobehavioral Dysregulation in Former American Football Players
In former American football players, the number of CAMs and higher average pain were associated with neurobehavioral dysregulation. No associations were observed with diagnosis of cognitive impairment by TES criteria, though the number of CAMs was associated with decreased MoCA.
Authors
- Steven Lenio (ORCID: https://orcid.org/0000-0003-1690-842X)
- Laura J. Balcer (ORCID: https://orcid.org/0000-0002-5136-4539)
- Douglas I. Katz (ORCID: https://orcid.org/0000-0002-7502-8505)
- Joseph Palmisano (ORCID: https://orcid.org/0000-0001-6000-3025)
- J Cummings
- Robert C. Cantu (ORCID: https://orcid.org/0009-0002-4300-4063)
- Jennifer V. Wethe (ORCID: https://orcid.org/0000-0003-2911-1129)
- Charles Adler
- Charles Bernick (ORCID: https://orcid.org/0000-0003-4040-3587)
- Michael L. Alosco (ORCID: https://orcid.org/0000-0002-8113-8428)
- EM Reiman
- William Barr (ORCID: https://orcid.org/0000-0001-7711-7758)
- Ina Hoti
- Martha E. Shenton
- Alexa Puleio
- Yorghos Tripodis
- David W. Dodick
- Brett Martin
- Robert A. Stern
- Jesse Mez
- Sarah J Banks
Institutions
- Boston University (US)
- Brigham and Women's Hospital (US)
- Cleveland Clinic (US)
- University of Nevada, Las Vegas (US)
- Lou Ruvo Brain Institute (US)
- University of California San Diego (US)
- Mayo Clinic in Arizona (US)
- Banner Alzheimer’s Institute
- New York University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108461
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00