Relationships of structural and load‐dependent arterial stiffness with cognition and AD/ADRD biomarkers: The Healthy Brain Study
Higher T-PWV, primarily due to structural remodeling, was associated with lower cognitive scores and higher white matter and gray matter structural abnormalities. In contrast, stiffness associated with blood pressure was associated with abnormalities in white matter integrity and abnormalities in white and gray matter blood flow. Interventions targeting arterial stiffness may be warranted to preserve cognition and cerebrovascular health.
Authors
- Megan E. Lipford (ORCID: https://orcid.org/0000-0003-1357-2131)
- Suzanne Craft (ORCID: https://orcid.org/0000-0003-0591-8657)
- Courtney L. Sutphen (ORCID: https://orcid.org/0000-0001-5005-2018)
- Ryan J. Pewowaruk (ORCID: https://orcid.org/0000-0003-1190-7196)
- Theodore M. DeConne (ORCID: https://orcid.org/0000-0002-9704-6499)
- Laura D. Baker (ORCID: https://orcid.org/0000-0002-6217-7384)
- Marc D. Rudolph (ORCID: https://orcid.org/0000-0001-7046-1169)
- Thomas C. Register (ORCID: https://orcid.org/0000-0002-4078-0166)
- M. A. Espeland
- Cynthia K. Suerken (ORCID: https://orcid.org/0000-0002-8589-524X)
- Adam D. Gepner (ORCID: https://orcid.org/0000-0002-5869-2850)
- Sam Lockhart
- Michelle M. Mielke (ORCID: https://orcid.org/0000-0001-7177-1185)
- T. G. Hughes
- Trey Bateman
Institutions
- Pew Research Center (US)
- University of Wisconsin–Madison (US)
- Wake Forest University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_101143
- Primary Topic
- Cardiovascular Health and Disease Prevention
- Type
- article
- Field-Weighted Citation Impact
- 0.00