Proctocolectomy with permanent ileostomy is associated with improved transplant-free survival in patients with PSC
The impact of the gut-liver axis in the pathophysiology of primary sclerosing cholangitis (PSC) has remained uncertain. In this study, proctocolectomy with ileostomy was associated with improved transplant-free survival, defined as a reduced risk of liver transplantation or PSC-related death, indicating that intestinal factors may influence disease progression. These findings are important for clinicians, researchers, and patients as they suggest that surgical management of colonic disease may have prognostic implications in PSC, and for further studies to clarify mechanisms and guide clinical decision-making.
Authors
- Kristin Kaasen Jørgensen (ORCID: https://orcid.org/0000-0002-3693-7706)
- Annika Bergquist (ORCID: https://orcid.org/0000-0002-3858-6241)
- Akin Inderson (ORCID: https://orcid.org/0000-0001-7644-0668)
- Jorn Goet (ORCID: https://orcid.org/0000-0002-6054-569X)
- Kirsten Muri Boberg (ORCID: https://orcid.org/0000-0001-5567-9928)
- Trine Folseraas (ORCID: https://orcid.org/0000-0003-2011-1923)
- Bregje Mol (ORCID: https://orcid.org/0000-0002-6428-9195)
- Mette Vesterhus (ORCID: https://orcid.org/0000-0003-1493-2303)
- Sara Kristina Viberg Tjønnfjord
- Rinse Karel Weersma (ORCID: https://orcid.org/0000-0001-7928-7371)
- A. S. W. De Vries
- Johannes R. Hov (ORCID: https://orcid.org/0000-0002-5900-8096)
- Johannes A. Bogaards (ORCID: https://orcid.org/0000-0002-3389-5141)
- Martti Färkkilä
- A. van der Meer
- Moyrha van Nieuwamerongen
- Cyriel Ponsioen
- Kim van Munster
Institutions
- Leiden University (NL)
- Oslo University Hospital (NO)
- University Medical Center Groningen (NL)
- Karolinska University Hospital (SE)
- University of Helsinki (FI)
- University of Oslo (NO)
- Akershus University Hospital (NO)
- Helsinki University Hospital (FI)
- Karolinska Institutet (SE)
- Netherlands Center for Occupational Diseases (NL)
- Amsterdam University Medical Centers (NL)
- University of Bergen (NO)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101700
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gilead Sciences
- ZonMw
- European Association for the Study of the Liver