Trained immunity attenuated acute lung injury by activating alveolar macrophages via AKT2-PDK1 axis-mediated metabolic reprogramming
We concluded that β-glucan induced trained immunity could enhance alveolar macrophage immune activity and improve lactate metabolic tolerance, offering a novel therapeutic approach for acute lung injury (ALI).
Authors
- Zhiheng Sun (ORCID: https://orcid.org/0000-0001-5462-9689)
- Z. Li
- Xinxin Li (ORCID: https://orcid.org/0000-0001-5624-5689)
- Wanyu He
- Huiwen Meng
- Yanlin Zhou (ORCID: https://orcid.org/0000-0003-3661-7929)
- Xinya Guo (ORCID: https://orcid.org/0000-0002-9156-6549)
- Ze Wang (ORCID: https://orcid.org/0000-0002-2571-8030)
- Yuan Wang
- Xinru Wang
Institutions
- Hospital of Hebei Province (CN)
- Hebei Yiling Hospital (CN)
- Hebei General Hospital (CN)
- Hebei Provincial Center for Disease Control and Prevention (CN)
- Henan Normal University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1186/s12967-025-06879-4
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Henan Normal University