Discrepant tau‐PET signal between [ <sup>18</sup> F]FTP and [ <sup>18</sup> F]MK6240 in low tau individuals
[<sup>18</sup>F]FTP shows meta-temporal retention not seen with [<sup>18</sup>F]MK6240 in low tau individuals. This discrepancy persists across transformed and z-scored images, suggesting that there is a difference in early tracer retention between [<sup>18</sup>F]FTP and [<sup>18</sup>F]MK6240. It is unclear if the early [<sup>18</sup>F]FTP retention is related to early maturity levels of tau or off-target signal. These findings have important implications for basic understanding of early tau retention, early diagnosis, and biomarker harmonization efforts.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Nesrine Rahmouni
- Renaud La Joie (ORCID: https://orcid.org/0000-0003-2581-8100)
- Belén Pascual (ORCID: https://orcid.org/0000-0002-4467-7406)
- Arthur C. Macedo (ORCID: https://orcid.org/0000-0002-3957-0284)
- Suzanne L. Baker (ORCID: https://orcid.org/0000-0003-0209-3127)
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- David Soleimani‐Meigooni
- Hsin‐Yeh Tsai
- Cécile Tissot (ORCID: https://orcid.org/0000-0002-5022-2213)
- Jenna Stevenson (ORCID: https://orcid.org/0000-0003-2848-1451)
- Hwamee Oh (ORCID: https://orcid.org/0000-0003-1156-5704)
- William J. Jagust
- Joseph Therriault
- Brian A. Gordon
- Stijn Servaes
- William E Klunk
Institutions
- Houston Methodist (US)
- Lawrence Berkeley National Laboratory (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- Brown University (US)
- McGill University Health Centre (CA)
- Mayo Clinic in Arizona (US)
- McGill University (CA)
- University of California, Berkeley (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_109000
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00