No Evidence for Cognitive Decline in First-Episode Psychosis: A Meta-Analysis of Long-Term Longitudinal Studies
Neuropsychological performance in FEP remains stable for at least a decade, with modest gains largely attributable to practice effects and no sign of neurodegenerative decline. These trait-like deficits appear partly independent of long-term symptom changes, and further support neurodevelopmental over neurodegenerative models of schizophrenia.
Authors
- Cemal Demirlek (ORCID: https://orcid.org/0000-0001-6195-6899)
- M. Keshavan
- Bora Emre
- Robin M Murray
Institutions
- Beth Israel Deaconess Medical Center (US)
- King's College London (GB)
- Dokuz Eylül University (TR)
Publication Details
- Journal
- Schizophrenia Bulletin
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1093/schbul/sbaf237
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00