The impact of blood‐brain barrier modulation by focused ultrasound on oligodendrogenesis for Alzheimer's disease
This first-of-its-kind study demonstrates that FUS stimulates oligodendrogenesis in the mouse hippocampus, including in the context of AD pathology. Exploring the process of FUS-induced oligodendrogenesis and gaining mechanistic insights will advance the understanding of FUS as a therapeutic modality for AD and other white matter diseases.
Authors
- Joseph Silburt (ORCID: https://orcid.org/0000-0002-4364-5277)
- Kate Noseworthy (ORCID: https://orcid.org/0009-0006-0604-2780)
- Isabelle Aubert (ORCID: https://orcid.org/0000-0001-5163-9961)
- Laura M. Vecchio (ORCID: https://orcid.org/0000-0003-1520-9336)
- Sheng‐Kai Wu
- Luis Fernando Rubio‐Atonal
- Kullervo Hynynen
- Brandy Laurette
- Alessia Apa
Institutions
- Sunnybrook Health Science Centre (CA)
- University of Toronto (CA)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_098200
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00