Evaluating the Link Between Thyroid Function Test Results and Levothyroxine Dose in the Management of Hypothyroidism: Can We Improve Dosing Regimes?
We have here described that distribution of FT4/TSH is different in people on and off Levothyroxine treatment. For those on Levothyroxine, only 43.8% were within the TSH reference range and the degree of difference increased in treated individuals with Levothyroxine daily dose. The potential implication of our findings is that clinicians must be mindful as they diagnose and treat hypothyroidism that the administration of Levothyroxine, while in most but not all individuals is clinically beneficial does not return the individual to the same balance of TSH and FT4 as seen in euthyroid individuals.
Authors
- Lakdasa Premawardhana (ORCID: https://orcid.org/0000-0003-0931-3700)
- Suhani Bahl (ORCID: https://orcid.org/0009-0002-3216-896X)
- Onyebuchi Okosieme (ORCID: https://orcid.org/0000-0003-2221-992X)
- Peter Nicholas Taylor (ORCID: https://orcid.org/0000-0002-3436-422X)
- Antonio Bianco
- Adrian H. Heald
- Anthony A. Fryer
- Michael P. Stedman
- Colin M. Dayan
Institutions
- Manchester Academic Health Science Centre (GB)
- Concord Consortium (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
- Salford Royal Hospital (GB)
- University of Wales Institute Cardiff (SG)
- Keele University (GB)
- Cardiff Metropolitan University (GB)
Publication Details
- Journal
- Clinical Endocrinology
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1111/cen.70074
- Citations
- 1
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.29