Cellular metabolism of peripheral CD8+ T cells in early cognitive impairment

Differences in NAD(P)H, a marker of glucose catabolism, can be observed in peripheral T cells in early cognitive impairment. CD8+ cellular metabolism appear to correlate with plasma biomarkers of neurodegeneration and AD, setting the stage for further investigation into the implications on CD8+ function and effect of metabolism-modifying drugs such as metformin on peripheral CD8+ T cells and AD progression.

Authors

Institutions

Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70861_108845
Primary Topic
Tryptophan and brain disorders
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Cellular metabolism of peripheral CD8+ T cells in early cognitive impairment

Jacklyn Leonardo, Gurveen Kaur Sandhu, Jia Hui Wong, Barrón Anna et al.
Alzheimer s & Dementia
Tryptophan and brain disorders
article

Cellular metabolism of peripheral CD8+ T cells in early cognitive impairment

Jacklyn Leonardo, Gurveen Kaur Sandhu, Jia Hui Wong, Barrón Anna, Nagaendran Kandiah, Jia Min Tan, Xin Ying Sim, Fatin Zahra Zailan
article en

Abstract

Differences in NAD(P)H, a marker of glucose catabolism, can be observed in peripheral T cells in early cognitive impairment. CD8+ cellular metabolism appear to correlate with plasma biomarkers of neurodegeneration and AD, setting the stage for further investigation into the implications on CD8+ function and effect of metabolism-modifying drugs such as metformin on peripheral CD8+ T cells and AD progression.

Alzheimer s & DementiaVol. 21(S7)
Nanyang Technological University (SG), Singapore Centre for Environmental Life Sciences Engineering (SG)
Openalex Percentile: Top 48%
Tryptophan and brain disorders
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Cellular metabolism of peripheral CD8+ T cells in early cognitive impairment — Jacklyn Leonardo, Gurveen Kaur Sandhu, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS