Multiple Beneficial Effects of AR1001 on Aβ‐Induced Changes in Human Minibrain
We found that AR1001 effectively clears oAβ and exhibits anti-inflammatory effects in astrocytes and microglia. It also provides significant protective effects in neurons, reducing p -tau levels. These findings highlight the multiple beneficial effects of AR1001 on key brain components: astrocytes, microglia, and neurons.
Authors
- Fred Kim (ORCID: https://orcid.org/0000-0001-6010-3544)
- Ju‐Suk Nam (ORCID: https://orcid.org/0000-0003-4437-3194)
- Jai Jun Choung
- Dong‐Keun Song (ORCID: https://orcid.org/0000-0002-9238-3816)
- Hyunji Jo
- Hansang Cho
- Kee‐Chan Ahn
Institutions
- Adone (South Korea) (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108692
- Primary Topic
- Phosphodiesterase function and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00