Exploring the Relationship Between HbA1c, APOE4 Status, and Fluid Cognitive Performance in Healthy Older Adults

In cognitively normal older adults without diabetes, E4 status had an interactive effect with HbA1c. We found that higher A1c predicted better cognitive performance in E4 non-carriers, but worse cognitive performance in E4 carriers. Understanding the interplay between metabolic factors, E4 status, and cognition can provide insight into AD risk and prevention. This is critical given ongoing research involving diabetes medications such as GLP-1s and their potential role in AD prevention.