LIfestyle for BRAin health (LIBRA) and cognitive functioning from young to old adulthood: Results of the German National Cohort (NAKO)
Our findings provide novel evidence suggesting that LIBRA is a useful tool in younger adulthood (20-39 years), a group still neglected in dementia risk research. Modifiable risk factors were already frequent in this age range and associated with lower cognitive functioning. The observed sex/gender and socioeconomic disparities indicate compounded disadvantages faced by lower SES groups and women, emphasising the need for tailored, ideally early interventions possibly targeting behavioural risk factors. Longitudinal studies could help to disentangle life-course dynamics of LIBRA factors and cognitive functioning.
Authors
- Kay Deckers (ORCID: https://orcid.org/0000-0003-1339-2974)
- Felix Wittmann (ORCID: https://orcid.org/0000-0003-3578-7977)
- Alexander Pabst (ORCID: https://orcid.org/0000-0003-0432-5681)
- Luca Kleineidam (ORCID: https://orcid.org/0009-0006-3309-6856)
- Steffi Gerlinde Riedel-Heller (ORCID: https://orcid.org/0000-0003-4321-6090)
- M. Wagner
- Colin Rosenau (ORCID: https://orcid.org/0009-0008-3392-8207)
- Sebastian Köhler (ORCID: https://orcid.org/0000-0002-2398-0609)
- Susanne Roehr
- Klaus Berger
- Melanie Luppa
Institutions
- University of Bonn (DE)
- Trinity College Dublin (IE)
- Maastricht University Medical Centre (NL)
- German Center for Neurodegenerative Diseases (DE)
- Maastricht University (NL)
- Leipzig University (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_106257
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00