Lifetime activity scores in women at risk for Alzheimer's disease and relationship with midlife memory and executive function

Findings demonstrate that in women at risk for Alzheimer's, engagement levels peak in adolescence and youth, and that domains of activity engagement are intercorrelated. Exploratory analysis showed positive correlations between dNA and verbal fluency, suggesting a link between cognitive flexibility and higher lifespan activity engagement. Moreover, reduced engagement in adulthood suggests women may be in need of lifestyle intervention at midlife. However, the single, negative correlation of dNA with delayed recall memory was unexpected. Lack of findings may be due to low power or may reflect our younger sample of cognitively healthy women.