How Sex, Frailty, and Neuropathology Modify the Relationship Between Antidepressant Exposure and Alzheimer's Disease: A Retrospective Study
Antidepressant use was significantly associated with increased odds of AD. When stratified by binary sex, antidepressant use was significantly associated with increased AD odds in females, but not in males. Antidepressant-AD association was not modified by sex, frailty, or NPI. There was a positive association between the FI and the frailty phenotype among those not missing frailty phenotype data. These findings highlight key insights for identifying more modifiable risk factors for dementia.
Authors
- Sanja Stanojevic (ORCID: https://orcid.org/0000-0001-7931-8051)
- Pilar Robinson Gonzalez (ORCID: https://orcid.org/0000-0002-4244-4772)
- Shanna Trenaman (ORCID: https://orcid.org/0000-0002-7982-4437)
- Melissa K. Andrew (ORCID: https://orcid.org/0000-0001-7514-8972)
- Lucy Y Eum
Institutions
- Dalhousie University (CA)
- Nova Scotia Health Authority (CA)
- Consortium canadien en neurodégénérescence associée au vieillissement
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_106470
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00