Ultra‐high resolution 7T T2*w <i>ex vivo</i> MRI patterns differentiate underlying FTLD pathology in behavioral variant FTD
Pathologic subtypes of bvFTD may have partially distinct cellular, laminar and regional patterns of pathology that can inform diagnosis and mechanisms of FTLD proteinopathies. Ultra-high resolution T2*w MRI with sufficient resolution to detect these differences in vivo could increase diagnostic accuracy of underlying pathology in bvFTD. Future quantitative work with histology validation will elucidate whole-hemisphere patterns of FTLD cellular pathology and facilitate in vivo MRI biomarker development.
Authors
- Alejandra Bahena
- James C. Gee (ORCID: https://orcid.org/0000-0002-2258-0187)
- Daniel T. Ohm (ORCID: https://orcid.org/0000-0002-7930-5434)
- Corey T. McMillan (ORCID: https://orcid.org/0000-0002-7581-6405)
- Noah Capp
- David A. Wolk (ORCID: https://orcid.org/0000-0002-3554-3481)
- Winifred Trotman (ORCID: https://orcid.org/0000-0002-4121-1889)
- Sheina Emrani
- Eric Teunissen‐Bermeo
- Sandhitsu R. Das (ORCID: https://orcid.org/0000-0003-0530-2887)
- Paul A. Yushkevich
- Eddie B. Lee
- David J. Irwin
- M. Dylan Tisdall
Institutions
- Penn Center for AIDS Research (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108813
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00