Polygenic Risk Scores for modifiable risk factors show sex‐specific associations in Alzheimer’s Disease
Our findings highlight that incorporating PRS into a sex-stratified framework can uncover differential influences of modifiable risk factors on AD. Future work using Mendelian Randomization will evaluate whether these risk factors have a direct causal impact on AD development.
Authors
- Aadrita Chatterjee (ORCID: https://orcid.org/0009-0002-6642-6541)
- Meri Okorie
- Yaffe Kl
- Ana I Boeriu
- Paulina Tolosa Tort
- Nia Spadoni
- Rakshya U Sharma
- Shea J Andrews
Institutions
- University of California, San Francisco (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108479
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00