Lifetime exposure to modifiable risks and later‐life cognition impairment: the British 1946 birth study

While several exposures were associated with cognitive impairment at 69yrs, mostly in a dose-response manner, the only robust independent relationships were for education and physical inactivity. Baseline cognitive function and social class are also important prediction exposures for later-life cognitive impairment. These findings emphasise the importance of promoting education, physical activity and improving earlier life socioeconomic status in dementia prevention strategies and demonstrate the potential of longitudinal cohort studies for exploring viable modifiable risks.