The utility of phosphorylated Tau‐217 in discriminating chronic traumatic encephalopathy and Alzheimer’s disease in postmortem cerebral spinal fluid and serum
Postmortem CSF and serum p -tau217 were significantly associated with AD. In contrast, neither CSF or serum p -tau217 showed associations with CTE diagnosis or severity. This suggests that p -tau217 may be helpful for discriminating AD from CTE. Discovery efforts are needed for development of fluid biomarkers with diagnostic utility for CTE.
Authors
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- Annalise E. Miner (ORCID: https://orcid.org/0000-0002-9336-2419)
- SA Hawkins
- Kelsey Goostrey (ORCID: https://orcid.org/0000-0002-5046-3287)
- Raymond Nicks
- Michael L. Alosco (ORCID: https://orcid.org/0000-0002-8113-8428)
- Laia Montoliu‐Gaya (ORCID: https://orcid.org/0000-0001-7684-6318)
- Caroline A. Kubilus
- Anna Aaronson (ORCID: https://orcid.org/0000-0002-5231-9684)
- Petra Ypsilantis
- Sophia Nosek
- Ann C. McKee
- Jenna R. Groh
- Thor D. Stein
- Kerry Cormier
- Renecca Mathias
- Shania C. Mulayi
- Matthew Roebuck
- Yorghos Tripodis
- Guglielmo Di Molfetta
- Elizabeth Spurlock
- Jesse Mez
- William S Cole‐French
Institutions
- Boston University (US)
- Banner Alzheimer’s Institute
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108171
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00