Neuroprotective effects of the neurotrophic factors carbamoylated erythropoietin and insulin‐like growth factor‐1 in Alzheimer’s disease

The data demonstrate a clear sex-specific difference in the neuroprotective effects of CEPO and IGF-1 in protecting against cognitive decline, with these neurotrophic factors being effective in male but not female mice. Our data also suggest that combining two neurotrophic factors may not be more effective than their individual treatment; however, more studies looking at different dosing and timing regimens should be pursued in the future.