Mapping Neuronal Circuits Regulating Temperature Preference and Sleep in Drosophila Alongside High‐throughput Epac Imaging of Synaptosome Subtypes

Our findings highlight that the neural circuits governing temperature preference and sleep overlap significantly, revealing their functional interdependence. Introducing Alzheimer's genes broadens our understanding of the underlying molecular mechanisms of impaired thermoregulation and sleep in neurodegenerative diseases. By leveraging behavioral assays and Drosophila genetics, this research provides key insights into conserved mechanisms and potential therapies for addressing sleep disorders and thermoregulatory dysfunctions in AD.