Thrombin generation profiling in rare coagulation factor deficiencies: associations with bleeding severity and potential for screening
Thrombin generation profiling correlated with bleeding severity and showed higher sensitivity than conventional screening assays in detecting RCFDs, supporting its potential in screening and clinical evaluation of RFCDs.
Authors
- Paul L. den Exter (ORCID: https://orcid.org/0000-0002-1543-5731)
- Bauke Haisma (ORCID: https://orcid.org/0009-0007-5149-8864)
- Joline L. Saes (ORCID: https://orcid.org/0000-0003-3219-4981)
- Marjon H. Cnossen (ORCID: https://orcid.org/0000-0003-1557-2995)
- Saskia E.M. Schols (ORCID: https://orcid.org/0000-0003-2423-2829)
- Laurens Nieuwenhuizen (ORCID: https://orcid.org/0000-0002-0494-9374)
- Karina Meijer (ORCID: https://orcid.org/0000-0001-9447-0465)
- Nicole M. A. Blijlevens (ORCID: https://orcid.org/0000-0002-1801-2072)
- Ilmar C. Kruis (ORCID: https://orcid.org/0000-0003-4118-4670)
- Waander L. van Heerde (ORCID: https://orcid.org/0000-0001-7101-8775)
- Nick van Es
- Sanna R. Rijpma
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- Utrecht University (NL)
- Dutch Cancer Society (NL)
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- Máxima Medisch Centrum (NL)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Amsterdam University Medical Centers (NL)
- Netherlands Haemophilia Society
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1016/j.jtha.2025.11.025
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00