Alzheimer’s Polygenic Risk Scores Associate with Atherogenic Lipids and Reduced CRP in Mid‐Life Women

In middle-aged women, elevated polygenic liability for AD is linked to an atherogenic lipid profile and lower CRP concentrations, largely driven by APOE but with detectable contributions from wider AD-associated pathways. These findings reinforce mechanistic ties between AD genetics, cholesterol homeostasis and systemic inflammation, and suggest that peripheral lipids could serve as quantifiable readouts of polygenic AD risk. Larger, longitudinal and multi-omic studies are needed to clarify causal pathways and to determine whether non-APOE genetic signals offer independent targets for dementia prevention.