Cortical Microstructure in AD Patients Treated with Lecanemab – Six‐Month Update on an Ongoing Real‐World Observational Study
We have introduced a promising real-world observational study that could shed light on the microstructural nature of amyloid-lowering treatment response and the debate about pseudo-atrophy. Microstructural imaging measures are sensitive treatment biomarkers that correlate with clinical changes. Future work with a larger dataset will investigate the potential prediction of clinical change using baseline cortical disarray measurements.
Authors
- Pegah Khosropanah (ORCID: https://orcid.org/0000-0002-5255-7631)
- Izumi Aida
- Kentaro Ohta
- Mario Torso (ORCID: https://orcid.org/0000-0002-5284-9167)
- Takashi Nakajima (ORCID: https://orcid.org/0000-0001-5105-6619)
- Gerard R. Ridgway (ORCID: https://orcid.org/0000-0002-7676-7860)
- Steven A. Chance (ORCID: https://orcid.org/0000-0001-6060-3805)
- Ian Hardingham
Institutions
- Oxford Medical Diagnostics (United Kingdom) (GB)
- Nishi Niigata Chuo National Hospital (JP)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_109939
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00