A blood lipidomic score and Alzheimer’s disease: associations and mediating mechanisms from two cohort studies
We developed a blood lipid score which could predict incident AD in two independent cohorts. The presence of the APOE ε4 exacerbated the association of dyslipidemia with AD risk. Neurodegeneration and immune system could be the mediating mechanisms.
Authors
- Wei Xu (ORCID: https://orcid.org/0000-0003-4208-7477)
- Lu Tan (ORCID: https://orcid.org/0000-0002-0399-7147)
- Chen‐Chen Tan
- Liangyu Huang
Institutions
- Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108128
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00