Cognitively Unimpaired Older Adults with Type 2 Diabetes have Higher Levels of Plasma <i>p</i> ‐tau217
T2D was associated with higher levels of plasma p -tau-217 compared with those who do not have T2D. This suggests T2D may promote early pathological changes that raise AD risk in cognitively unimpaired older adults (Ashton et al., 2022). These results build on our earlier work demonstrating that T2D and associated hyperglycemia may lower medial temporal lobe cognitive function in cognitively unimpaired older adults, which may be mediated by increased AD neuropathology.
Authors
- Henrik Zetterberg
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- Maureen W. Gichura
- Miray Budak (ORCID: https://orcid.org/0000-0003-0552-8464)
- Robert Perna
- Bisma Iqbal
- Stanley Romain
- Ashley Powell
- Mark A. Gluck (ORCID: https://orcid.org/0000-0003-0538-2303)
- Kaj Blennow
- Steven K. Malin (ORCID: https://orcid.org/0000-0002-7360-6711)
- Darian A. Napoleon
- Salma M Abedullah
- Fanny Elahi
- Wiktoria Piaszczynska
- Andrea Dickantone
- Mc Derby Ceneus
- Patricia Fitzgerald‐Bocarsly
- Bernadette A. Fausto
- Harrison W Chan
Institutions
- Rutgers, The State University of New Jersey (US)
- University of Wisconsin–Madison (US)
- Hong Kong Science and Technology Parks Corporation (HK)
- Sahlgrenska University Hospital (SE)
- MRC Prion Unit (GB)
- University College London (GB)
- University of Gothenburg (SE)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108860
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00