Lifestyle and health signatures of brain pathological and cognitive aging
Our results suggest that factors of cognitive resilience and brain maintenance are to some extent unified in an active lifestyle described by physical fitness, mental leisure activities, and lower cardiovascular risk. In addition, engagement in mental leisure activities may explain cognitive resilience independent of brain pathology. Finally, genetic risk for AD may also accelerate brain aging in cognitively healthy older adults.
Authors
- Emrah Düzel (ORCID: https://orcid.org/0000-0002-0139-5388)
- Anne Hochkeppler
- Jose Bernal Moyano
- Niklas Vockert (ORCID: https://orcid.org/0000-0001-5915-2517)
- Osama Sabri
- Berta Garcia‐Garcia (ORCID: https://orcid.org/0000-0002-8585-6507)
- Svenja Schwarck (ORCID: https://orcid.org/0000-0003-2024-9236)
- Larissa Fischer (ORCID: https://orcid.org/0009-0001-9936-2954)
- Enise Irem Incesoy (ORCID: https://orcid.org/0000-0003-2014-4098)
- Hermann Esselmann (ORCID: https://orcid.org/0000-0001-5484-9710)
- Bárbara Morgado (ORCID: https://orcid.org/0000-0001-8174-9301)
- Michael C. Kreißl (ORCID: https://orcid.org/0000-0001-5905-6015)
- Beate Schumann‐Werner (ORCID: https://orcid.org/0000-0002-3530-5766)
- Eóin N. Molloy (ORCID: https://orcid.org/0000-0002-7804-2214)
- Patrick Müller (ORCID: https://orcid.org/0000-0001-7458-2208)
- Jens Wiltfang
- Niklas Behrenbruch
- Anna‐Therese Büchel
- Gusalija Behnisch
- Anne Maass
- Björn H. Schott
- Henryk Barthel
- Constanze I. Seidenbecher
Institutions
- German Center for Neurodegenerative Diseases (DE)
- Universitätsmedizin Göttingen (DE)
- University Hospital Magdeburg (DE)
- University of Göttingen (DE)
- Leipzig University (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- Leibniz Institute for Neurobiology (DE)
- University of Edinburgh (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_109741
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00