PTEN deficiency linked to chromosome 10q loss leads to aggressive NF2 mutant meningioma biology
PTEN loss causally drives aggressive NF2 mutant meningiomas, and cross-species integration provides a novel, high-fidelity system to validate preclinical models to human disease.
Authors
- Sonali Arora (ORCID: https://orcid.org/0000-0002-6661-3024)
- Philipp Sievers
- Prof Felix Sahm
- Abigail Grace Parrish
- Christel Herold-Mende
- Eric Holland
- Frank Szulzewsky
- Heshani Nayanga Thirmanne
Institutions
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- University of Utah (US)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Fred Hutch Cancer Center (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-22
- DOI
- https://doi.org/10.64898/2025.12.21.695820
- Citations
- 1
- Primary Topic
- Meningioma and schwannoma management
- Type
- article
- Field-Weighted Citation Impact
- 1.35