Associations between herpes zoster vaccination and herpes zoster with dementia risk in APOE‐e4 carriers and non‐carriers
Our findings support previous research indicating a reduced risk of dementia among HZ-Vx recipients. We uniquely showed the potential effect in both APOE-e4 carriers and non-carriers. Conversely, we observed an increased risk of dementia in individuals with a recorded HZ diagnosis in the younger age group. Further research is required to understand the role of HZ as a potential risk factor for dementia.
Authors
- John A. Todd (ORCID: https://orcid.org/0000-0003-2740-8148)
- Ana Torralbo (ORCID: https://orcid.org/0000-0003-2738-8503)
- Andrew M. Goldfine (ORCID: https://orcid.org/0000-0003-1962-5564)
- Robert A. H. Scott (ORCID: https://orcid.org/0000-0001-9822-7825)
- Chun‐Fang Xu (ORCID: https://orcid.org/0000-0002-8747-0683)
- Jessica Chao (ORCID: https://orcid.org/0000-0001-8208-8939)
- Maxime Taquet (ORCID: https://orcid.org/0000-0002-8987-952X)
- Paul Harrison (ORCID: https://orcid.org/0000-0003-4610-8909)
- Cai Ytsma
- Natalie K. Fitzpatrick (ORCID: https://orcid.org/0000-0001-5000-2520)
- Spiros Denaxas
- Ian J Douglas
- Usha Gungabissoon
- Jonathan Davitte
- Jorge Esparza Gordillo
- Chris Tomlinson
Institutions
- Age UK (GB)
- Oxford Health NHS Foundation Trust (GB)
- London School of Hygiene & Tropical Medicine (GB)
- GlaxoSmithKline (United States) (US)
- Oxford BioMedica (United Kingdom) (GB)
- University College London (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_104034
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00