Brain Transcriptome Analysis Identifies Sex‐Associated Synaptic and Immune‐Associated Genes Involved in Alzheimer's Disease and Psychiatric Disorders

This study highlights the critical role of sex-specific gene expression in brain disorders, particularly psychiatric disorders and AD. Synaptic and immune-associated pathways, mediated by key sex-associated genes such as NRXN2 and INPP5D, emerge as potential modulators of neurological disorders. These findings deepen our understanding of sex-specific brain pathophysiology and offer a foundation for developing personalized therapeutic strategies targeting these mechanisms.